First form: Wily Machine 2 goes back and forth using energy shots that go down and rise in an arch to the top of the screen. It is very weak to Atomic Fire, being defeated with two fully charged shots or less, depending on the difficulty. If the player used Atomic Fire on Wood Man and there is no energy left for a charged shot, it is recommended to use Crash Bomber or Metal Blade. When all of its health is depleted, the front part of the machine will blow up and Wily will appear.
Second form: Damaged, the Wily Machine 2 now shoots multiple bouncing balls that are difficult to avoid. This form is now immune to Atomic Fire, but is still vulnerable to Crash Bomber (and can be destroyed with a single Crash Bomb explosion if it is aimed and timed properly), but since the player is most likely going to be low or out of Crash Bomber from the previous fight, it is best to use Metal Blades or Air Shooter. The player should use his weaknesses to defeat him quickly and use E-Tanks if necessary. After destroying the Wily Machine, the floor will blow up with the Wily Machine and the player will fall to the last level, leading to the final battle against the Alien.
Wily Machine 2 is also used by Wily in the cartoon Captain N: The Game Master. Although this machine appeared in from the second game, in the cartoon it is used in the episode "Mega Trouble in Megaland", which is based on the first game.