He is fought twice in the game. In his stage he attacks with a rod that can extend, and can spin it fast to protect against attacks. He also creates illusions of himself when he jumps to other side of the room. After his defeat, he escapes (having only 1 HP left) and is fought again in the third Wily Tower stage, where he attacks with shots from his arm cannon and jumps from platforms that are constantly falling down. His weakness is Hard Knuckle.
In the manga, Buster Rod G was created with lightweight materials to make him fast, but as result he has low resistance to damage. He has a hologram generator similar to the one used by Gemini Man, allowing him to produce multiple images of himself and confuse enemies. He appears in the side story "Mega Gandhara" and has a cameo appearance in the last story from Mega Man Gigamix.
Buster Rod G first appeared in issue 20, where the Genesis Unit and the Mega Man Killers help Dr. Wily invade the Chronos Institute in an event that will happen in the future. He appears again during the crossover Worlds Collide, joining the rest of the Genesis Unit and Copy Robot to attack Mega Man, Sonic the Hedgehog, Proto Man, Tails, and Rush. Buster Rod G battled Sonic, but was defeated by the Hedgehog. He and the rest of the Genesis Unit had been completely destroyed by Mega Man beforehand in the altered timeline created by the Genesis Wave, down to their IC chips, which should have made reconstruction impossible. However, due to the altered laws of reality in the Skull Egg Zone, they were revived by Dr. Wily and Dr. Eggman. Buster Rod and his comrades were later revived again as part of a large Robot Master army that battled the blue heroes and their force of allies, but the monkey-like Robot Master was once again overpowered by Sonic.
Mega Man fighting against Buster Rod G in the Wily Tower.
Buster Rod G is one of two characters featured in Archie Comics series based on video games to have been based on Sun Wukong, the other being Ken "Monkey" Khan from the Sonic the Hedgehog series. A nod to this shared basis is made during Buster Rod G and Sonic's first fight, which Sonic notes feels "familiar."