After delivering the Chaos Emerald to the doctors, Rose Woman and other Roboticized Masters later encountered Sonic, Tails, Mega Man, Rush, and Proto Man in the Skull Egg Zone, although she left to confront Proto Man with the other robots, save for Espio Man, Charmy Man, and Vector Man, who confronted Sonic, Tails, Mega Man, and Rush. (Sonic Universe #52 and Sonic the Hedgehog #249)
Rose Woman, alongside Knuckles Man, eventually found both Proto Man and the restored Chaotix Roboticized Masters (Espio the Chameleon, Charmy Bee, and Vector the Crocodile, respectively), but they were ordered to go after Sonic and Mega Man and defeat them by any means, announcing that their self-destruct protocol had been activated. They later encountered Sonic, Tails, and Rush, with their self-destruct protocols remaining active (ironically, she and Knuckles Man warped in to ambush them just as Sonic wished that they ambush them). Mega Man was barely able to deroboticize them in time with the Sonic Blast. Amy Rose, upon reasserting her identity, then proceeded to glomp Sonic as usual and excuse for what she had done.